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Niigata University Faculty of Dentistry

Among the National University Corporations, Niigata University Faculty of Dentistry with its Medical and Dental Hospital is the sole dental educational institution on the Japan sea coast. The Faculty has always played a central role in fostering the advancement of dental science and progressive treatment in the entire Far East.

The Faculty of Dentistry was established in 1965, and has the third longest history in all Japanese National University Corporation dental faculties, for four decades, the Faculty has always had the objective of pursuing a higher level of education, research and dental therapy.

The Faculty of Dentistry is located in the center of Niigata city, it is part of the major regional medical center formed by the adjacent Medical Faculty, the University Medical and Dental Hospital, and the Brain Research Institute.

Research Activities and Subjects in Each Department

Department of Oral Health Science

Div. of Oral Ecology in Health and Infection
  • Microbiological and immunological approach to dental caries and periodontal diseases
  • Ecological characteristics of oral flora
  • Oral anaerobes and their pathogenic roles
  • Immuno-chemical structures of oral bacterial antigens
  • Lesion sterilization and tissue repair (LSTR) therapy
Div. of Biomaterial Science
  • Fundamental and clinical studies of the applications of titanium in dentistry:
    Casting defects; Development of a visualization technique for molten metal flow in a mold cavity
     Mechanism of casting defect formation by observation of the molten metal flow
    Clinical applications; Soldering titanium
      Adaptability and internal defect of cast titanium crowns
    Reaction with investments; Reaction layers in cast titanium surfaces
     Development of investments for titanium casting
    Reaction with abrasives; Surface contamination of abraded titanium
     Development of grinding, abrading and finishing techniques
    Reaction with bio-tissues; Surface structure and corrosion of implanted titanium
      Surface structure and bio-compatibility of titanium
  • Biomechanical studies of dental implants:
  • Three-dimensional finite element analysis of stress in surrounding bone Computer-aided design of dental implants
  • Synthesis of fine ceramic powders by the sol-gel method and application in dentistry
  • Study of metal-porcelain bonding (high temperature oxidation of alloys, interface reactions and improvement of fusing techniques)
  • Fracture mechanics of bonding strength of metal-resin and metal-porcelain composites
  • Study of setting behavior of phosphate-bonded investments
Div. of Preventive Dentistry
  • Identification of predictors for dental caries and root caries, and the reconstruction of clinical preventive programs by the risk level
  • Dento-sociological studies on the extensive use of fluoride for dental caries prevention
  • Identification of the risk factors of periodontal diseases and attempt to construct disease models in population level
  • Epidemiological study of malocclusion assessed according to social acceptability
  • How can oral health conditions contribute to general health protection and promotion in older age groups
  • Development of community based oral health programs and systems
  • Development of oral malodor screening method and clinical approach to oral malodor patients
Div. of Cariology Operative Dentistry and Endodontics
  • Evaluation of caries-inhibiting properties of fluoride-releasing restorative materials
  • Application of lasers in biological caries treatment
  • Studies on CAD/CAM ceramic crowns: evaluation of adaptation, and clinical application
  • Morphogenesis and regeneration of dentin/pulp complex: Investigation into the mechanisms, and development of dentin regeneration therapy
  • Studies on biofilms: Analysis of virulence, and development and clinical application of cleaning strategies
  • Microendodontics
  • Evaluation of simulation systems for clinical education
  • Evaluation of root canal preparation using Ni-Ti rotary files
Div. of Pediatric Dentistry
  • Physiological analyses and clinical evaluation of development in chewing and swallowing
  • Studies on mechanism of tooth eruption and occlusion
  • Immunohistochemical and genetic approach for development of teeth
  • Pathogenesis and preventive strategy of dental caries in child patients
  • Treatment planning of child patients with general diseases
  • Behavior management of difficult child patients during dental treatment
  • Morphological analyses of growth of maxillo-facial complex
Div. of Oral Health in Aging and Fixed Prosthodontics
  • Clinical studies of crown and bridge restorations
  • Investigation on biological aspects of Prosthodontics
  • Basic and clinical studies of dental implants
  • Studies of metal allergy
  • Studies of lasers in dentistry
  • Studies on the prosthetic use of titanium
  • Investigation of the changes associated with aging in the stomatognathic functions
  • Diagnosis and treatment methods required for the maintenance and restoration of oral functions in the elderly
Div. of Oral and Maxillofacial Surgery
  • Genetic analysis of patients with cleft lip and/or palate
  • Clinical evaluation on jaw growth of patients with cleft lip and/or palate
  • Clinical evaluation on nasopharyngeal (speech) functions after two-stage palatoplasty for patients with cleft palate
  • Randomized control trial of primary surgery for patients with cleft lip and/or palate
  • Clinical evaluation on nasopharyngeal (speech) function after surgical advancement of maxilla for patients with cleft palate
  • Clinical evaluation on stability of occlusion after orthognathic surgery for patients with jaw deformities
  • Experimental study on hyperthermic oncology of oral cancer
  • Development of diagnosis system of the oral cancer by gene expression analysis
  • Genetic analysis of patients with various kinds of diseases originating from oral mucosa
  • Epidemiological research on signs and symptoms around temporomandibular joints
  • Ultrastructural studies on function and development of the temporomandibular joints
  • Clinical research on pathogenesis of temporomadibular joint disorders
  • Clinical studies on relationship between reconstruction of jaws and oral functions (swallowing and occlusion)
  • Clinical and experimental studies on alveolar bone augmentation

Department of Oral Biological Science

Div. of Oral Anatomy
  • Ultrastructural and cytochemical study of tooth morphogenesis and calcification
  • Immunocytochemical and ultrastructural study of the sensory mechanism in dental pulp and periodontium
  • Histological and immunohistochemical study of tissue response to tooth transplantation, replantation, and implantation
  • Ultrastructural and developmental study of synovial membrane of temporomandibular joint
  • Cellular and molecular assessment on the biological mechanism on bone and cartilage development
  • Histological evaluation of cell proliferation and differentiation on dental implantation and bone grafting
  • Cytological and histological study on the biological action of osteotropic hormones
  • Immunocytochemical study of the distribution and role of antigen-presenting cells in dental pulp and periodontium
  • Ultrastructural study of the mechanism on tooth morphogenesis using gene-knock out mice
  • Cytochemical study of ectopic calcification
Div. of Oral Physiology
  • Neural control mechanisms of the jaw movement
  • Oral sensations and related reflexs
  • Neurophysiological approach to the taste mechanism
  • Neural control mechanisms underlying swallowing movements
  • Neurophysiological approach on the mechanisms underlying bruxism and clenching
  • Relationships between jaw muscle activity and orofacial pain
  • Somatic sensation and its control during mastication
Div. of Developmental Biology
  • Molecular and cellular biological studies of
  • mammalian organogenesis
  • regulatory mechanism of neural crest cell differentiation
  • cleft lip/palate and defects in tooth development
  • tooth regeneration
Div. of Periodontology
  • Immunological and genetic approach on the onset and progression of periodontal diseases (gingival tissues and gingival crevicular fluid and blood).
  • Establishment of examinations for periodontal disease activity and susceptibility.
  • Regeneration and reconstruction for periodontal tissues (growth factor, GTR, GBR, bone graft, PRP, enamel matrix protein, Tissue Engineering)
  • Clinical comprehensive approach for implant, tooth transplantation, laser and the periodontal ligament.
Div. of Orthodontics
  • Facial esthetics and orthodontic treatment
  • Orthognathic surgery for jaw deformities
  • Adult orthodontics and Ortho-Perio remedy
  • Periodontal alterations associated with orthodontic treatment
  • Abnormal functions of cleft lip and/or palate patients
  • Biomechanical analysis of the orthodontic tooth and jaw movement
  • Orthodontics in TMD patients
  • Effect of orthodontic treatment on the neuro-muscular system
Div. of Dysphagia Rehabilitation
  • Studies on the aging mechanism of the oral region at genetic, molecular, cellular, tissue, organ and ontogenic levels
  • The eitological, preventive, diagnostic and therepeutic studies on the various oral diseases and dysfunctions caused by aging
  • Studies on the oral care and rehabilitation of the aged and diseased persons
  • Establishment of objective assessment and rehabilitation approach for dysphagia
  • Enzymologic and morphological studies on the causes of taste disorder

Department of Tissue Regeneration and Reconstruction

Div. of Anatomy and Cell Biology of the Hard Tissue
  • Development and regeneration of dentin/pulp complex
  • Epithelial mesenchymal interaction during tooth development
  • The mechanism of tooth morphogenesis using gene-knock out mice
  • The immune defense mechanism of dental pulp
  • Cell biology of biomineralization in hard tissue
  • Cytochemistry and molecular biology of hard tissue formation and resorption
  • Histochemical and molecular biological studies on regulation of bone metabolism
  • Morphological studies on aging of bone
  • Cell biology on bone induction by biomaterials
  • Bone morphometry using new microscopies
Div. of Biochemistry
  • Molecular basis of Hypophosphatasia
  • Biosynthesis and targeting of parathyroid hormone-related peptide (PTHRP)
Div. of Oral Pathology
  • Structure and function of basement membrane type heparan sulfate proteoglycan
  • Stromal remodeling in the process of proliferation, invasion and metastasis of tumor cells
  • Epidemiologic and molecular pathologic study on salivary gland tumors
  • Tooth development failure and metabolism of extracellular matrix molecules
  • Intraepithelial stroma: its existence and function for tissue nutrition and migration of inflammatory cells
  • Pathogenesis of odontogenic tumors and cysts
  • Clinical and molecular pathologic study on recurrent superficial carcinomas of the oral mucosa
  • Oral cytology: its clinical significance and accuracy
Div. of Cell Biology and Molecular Pharmacology
  • The ultimate goal of our study is to elucidate the molecular mechanism of and provide the basis on clinical application for repair, regeneration and genesis of hard tissues such as bone and cartilage as well as periodontal tissue including the periodontal ligament.
      Research projects include:
  • Molecular mechanism of osteoblast differentiation
  • Molecular mechanism of osteogenesis
  • Mechanisms of mechanical stress-induced osteogenesis
  • Regulatory mechanisms of gene expression and cell differentiation
  • Effects of estrogens and SERMs (Selective Estrogen Receptor Modulators) in differentiation and function of the cell
  • Differentiation and function of the periodontal ligament
  • Characterization of cell lines for periodontal ligament fibroblasts
  • Identification of a marker(s) of periodontal ligament cell
  • Regulation of genes responsible for those processes described above
  • Regulatory mechanism of differentiation and function of tendon/ligament cells
Div. of Removable Prosthodontics
  • Analysis of the function of the stomatognathic system from a bio-mechanical approach
  • Causative mechanism of temporomandibular disorders and evaluation of its treatment through occlusal therapy
  • Control mechanisms of jaw movements
  • Clinical evaluation of mastication and swallowing function
  • Occlusal restoration of the partially and completely edentulous geriatric patients
  • Bacteriologic changes in the oral environment and its relation to the aging process
  • Histocytological and cytochemical study of aging in jaw bones
  • Clinical applications of fine ceramics and titanium in dentistry
  • Development of a robotic system for the simulation of mandibular movement
Div. of Oral and Maxillofacial Surgery
  • Diagnosis and treatment of oral cancer
  • Experimental and clinical study of metastasis of oral cancer
  • Orthognatic treatment of jaw deformities
  • Diagnosis and treatment of sleep apnea syndrome
  • Experimental and clinical study of bone graft in cleft in lip and palate and cancer
  • Experimental and clinical study of tooth transplantation
  • Physiological and clinical study of temporomandibular joint disorders
  • Pathological and clinical study of jaw cysts and odontogenic tumors
  • Clinical application of computers
  • Clinical and biomechanical study for jaw implant
  • Experimental and clinical study of tissue regeneration (Oral mucosa, Mesenchymal stem cells)
Div. of Oral and Maxillofacial Radiology
  • Diagnostic imaging of maxillofacial regions
  • Studies of the diagnosis of metastatic lymphadenopathy in head and neck cancer
  • Studies of alleviating the adverse events after radiation therapy for head and neck cancer
  • Diagnostic imaging of the temporomandibular joint
  • Studies on the diagnostic reliability of imaging modality for treatment planning of dental implants
Div. of Dental Anesthesiology
  • Application of patient controlled sedation using propofol in dental practice
  • Studies on the development of new treatments for chronic pain in the orofacial area
  • Clinical and experimental studies of the physiological and anatomical changes of the upper trachea in oral surgery
  • Studies on the activation mechanism of the intrinsic descending inhibitory system in the trigeminal area
  • Studies on an new treatment for the dental psychosomatic disorder

Faculty of Dentistry, Niigata University
2-5274, Gakkocho-dori, Chuo-ku, Niigata, 951-8514, JAPAN |TEL|+81-25-223-6161 |FAX|+81-25-227-0803

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