Div. of Anatomy and Cell Biology of the Hard Tissue

Professor　 OHSHIMA Hayato

histoman@dent.niigata-u.ac.jp

Our Education

　Anatomy
　Oral Anatomy
　Dental Anatomy

Our Research

　　We believe that it is the mission of the Department of Anatomy to provide the morphological basis for dental research. Taking a broad perspective, we aim to foster collaborative research with clinical and other basic divisions, cultivate core research themes within our department, and actively engage in joint research with external partners.
　　The three major research themes of the Division of Anatomy and Cell Biology of Hard Tissue are research on the morphogenetic mechanisms of tooth and craniofacial development, research on the development and regeneration of the dentin/pulp complex, and research on risk assessment of complications during dental implant surgery and osseointegration after dental implantation. Our division has an environment and teaching system conducive to implementing morphological research methods, and it has established animal experimental systems using mice (cavity preparation, tooth replantation/transplantation, tooth germ transplantation, and dental implantation) that are relevant to clinical dentistry. In addition, our division owns and is conducting research using various transgenic mice (TetOP-GFP, osteopontin-KO, Nestin-GFP, K14-Cre, Wnt1-Cre, and Atg7flox/flox).
　　In addition to her proteoglycan research, Dr. Hiroko Ida-Yonemochi has made progress in research on tooth and bone regeneration using enzymatically synthesized glycogen. She has also focused on the intracellular glycogen accumulation process during organogenesis, elucidating novel mechanisms of carbohydrate metabolism during tooth and craniofacial development and autophagy research. Dr. Angela Quispe-Salcedo is dedicated to pulp biology research. Other research in our division includes the development of osteopontin peptide-coated implant and dendritic cell activation strategies in collaboration with the National Institute for Materials Science, as well as dental implant and tooth replantation research in combination with platelet-rich plasma. Dr. Masayuki Tsuneki, a board member of Medmain Inc. (a pioneering company in the development of artificial intelligence models for pathology image analysis), has published many results of artificial intelligence research.
　　Our division is also involved in macroscopic anatomy research. We were able to clarify the running pattern of arteriovenous vessels in the sublingual space, where damage to arteries during implant surgery can cause bleeding in the floor of the mouth, leading to life-threatening airway obstruction. In addition, we gained new insights into the running patterns of the superior alveolar nerve and blood vessels, infraorbital nerve branches, and lingual nerve as well as the facial muscles and fasciae. Our experience in teaching both macroscopic and microscopic anatomy in dental school has been a major driving force in our macroscopic anatomy research.

Our Website

https://www5.dent.niigata-u.ac.jp/~hard-tissue/

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• Departments/Faculty
  • Div. of Microbiology and Infectious Diseases
  • Div. of Biomimetics
  • Div. of Preventive Dentistry
  • Div. of Cariology Operative Dentistry and Endodontics
  • Div. of Pediatric Dentistry
  • Div. of Bio-Prosthdontics
  • Div. of Oral and Maxillofacial Surgery
  • Div. of Dental Clinical Education
  • Div. of Oral Anatomy
  • Div. of Oral Physiology
  • Div. of Oral Biochemistry
  • Div. of Periodontology
  • Div. of Orthodontics
  • Div. of Dysphagia Rehabilitation
  • Div. of Anatomy and Cell Biology of the Hard Tissue
  • Div. of Oral Pathology
  • Div. of Dental Pharmacology
  • Div. of Comprehensive Prosthodontics
  • Div. of Reconstructive Surgery for Oral and Maxillofacial Region
  • Div. of Oral and Maxillofacial Radiology
  • Div. of Dental Anesthesiology
  • Department of Oral Health and Welfare
  • Center for Advanced Oral Science
  • Div. of Dental Clinical Education
    General Dentistry and Clinical Education Unit
  • Oral Implant and Temporomandibular Joint Clinic