Center for Advanced Oral Science

Professor　 MAEDA Takeyasu

maedat@dent.niigata-u.ac.jp

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Our Education

Osteoimmunology, Bone Metabolism, Periodontology, Immunology, Anatomy, Oral Anatomy, Oral Histology and Embryology

Our Research

The center covers a wide range of research fields from anatomy to immunology and clinical periodontology. A lab meeting and journal club in English are held once a week. The center is installed with the latest experimental equipment (single-cell analyzers, fluorescence microscopes, gene amplifiers, frozen section preparation equipment, and cell culture equipment) to promote productive and high-quality research.
A group led by Prof. Takeyasu Maeda and Assistant Prof. Yurie Sato studies the regeneration mechanism of peripheral nerves in addition to the sensory reception mechanism in the orofacial region using morphological and molecular biological techniques. Their research results have been cited in many textbooks, and Prof. Maeda has been involved in editing various textbooks for dental students. He also conducts research on the advancement of dental education.
A group led by Associate Prof. Tomoki Maekawa and Assistant Prof. Andrea Rosenkranz aims to elucidate the mechanisms of tissue repair and regeneration with a focus on the stem cell niche using mouse and molecular biological techniques. Furthermore, they are working on the development of new drugs that can eliminate senescent cells and activate mesenchymal stem cells, and they are promoting industry–academia collaborations and translational research by patenting these new drugs. We are also promoting collaborative research with clinical departments to create models of bisphosphonate-related osteonecrosis of the jaw and periodontitis, which are often seen in clinical dentistry, and to develop treatment methods for these diseases. Moreover, we are directing our attention to the oral cavity, known for its well-preserved ancient samples. Our goal is to analyze the genetic structural changes that have unfolded over billions of years of evolution, as well as the environmental shifts spanning hundreds of thousands of years. This interdisciplinary effort involves collaboration among the fields of medical, dental, and pharmaceutical engineering, anthropology, and paleopathology. We are engaged in international joint research with partners from Japan, the United States, and Germany.
Assistant Prof. Yurie Sato studies the mechanism of degeneration and regeneration of the peripheral nervous system and neuropathic pain. Our primary goal is to elucidate the mechanism of orofacial neuropathic pain caused by damage of the trigeminal nerve. Our projects utilize a wide breadth of technologies based on mouse/rat genetics, histology, molecular biology, and physiology. In addition, we use disease models involving mutant mice and rats to further understand disease processes and target new factors for treatment.

Clinical Fields

Associate Prof. Maekawa is promoting clinical research in collaboration with companies in the development and clinical application of drugs that induce bone regeneration.

Our Website

https://www.caos-niigata-univ.net/

Our Citizenship

Prof. Maeda has served as an official committee member (Ministry of Education, Culture, Sports, Science and Technology; Ministry of Health, Labour and Welfare) and has contributed to the improvement and enrichment of dental education in Japan. In addition, Prof. Maeda and Associate Prof. Maekawa serve as editorial committee members for several international academic journals and reviewers for various research grants, further contributing to scientific advances.

Research Figures

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